Regulation of the Virulence Determinant OspC by bbd18 on Linear Plasmid lp17 of Borrelia burgdorferi
نویسندگان
چکیده
منابع مشابه
Purification and properties of the plasmid maintenance proteins from the Borrelia burgdorferi linear plasmid lp17.
The Lyme disease spirochete Borrelia burgdorferi carries more plasmids than any other bacterium, many of which are linear with covalently closed hairpin ends. These plasmids have also been referred to as mini-chromosomes and essential genetic elements and are integral components of its segmented genome. We have investigated two plasmid maintenance proteins, BBD14 (the replication initiator) and...
متن کاملThe cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid.
Borrelia burgdorferi B31 cells lacking all linear plasmids or all but the 49-kb linear plasmid expressed the otherwise silent gene for the outer membrane protein OspC. In the first demonstration of a function for a circular plasmid of Borrelia spp., ospC was located on a 27-kb circular plasmid of B31.
متن کاملEvolution and Distribution of the ospC Gene, a Transferable Serotype Determinant of Borrelia burgdorferi
Borrelia burgdorferi, an emerging bacterial pathogen, is maintained in nature by transmission from one vertebrate host to another by ticks. One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. Intragenic recombination among ospC genes is known, but the extent to which recombination extende...
متن کاملon the effect of linear & non-linear texts on students comprehension and recalling
چکیده ندارد.
15 صفحه اولOspC is potent plasminogen receptor on surface of Borrelia burgdorferi.
Host-derived proteases are crucial for the successful infection of vertebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi. B. burgdorferi must traverse tissue barriers in the tick vector during transmission to the host and during dissemination within the host, and it must disrupt immune challenges to successfully complete its infectious cycle. It...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2011
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.01496-10